Adipokines from adipose tissue and common variable immunodeficiency: Is there any association?

Abstract Adiponectin and leptin are adipokines, secreted by white adipose tissue (WAT), which play an important role in energy homeostasis. Some evidence has shown that adipokine‐producing cells present the bone marrow (BM) appear to exert influence on hematopoiesis B cell development. Common variable immunodeficiency (CVID) is one of most common inborn errors immunity humans. In CVID, numerical and/or functional defects their precursors result hypogammaglobulinemia, usually Immunoglobulin (Ig) A IgG. Manifestations CVID include immunodeficiency, autoimmunity, inflammation lymphoproliferation, resulting a wide range phenotypes. How adipokines interact pathophysiology still unclear. this review, we seek summarize aspects known so far concerning interface between CVID. More research needed fully understand these interactions; knowledge potential avenue for discovery useful biomarkers may provide new therapeutic targets treatment patients with related diseases.